Molecular Separation Man of India

Molecular Separation Man of India

Molecular Separation Man of India

Leaving DRDO in 1997 was a leap of faith for me. I had spent 15 years working with missiles, developing India’s first titanium air bottle and facilitating the industry interface for the indigenous production of astronautical-grade aluminium alloys, as well as AKASH missile airframes. By creating a special stainless steel to make an indigenous coronary (Kalam-Raju) stent, I opted to work on the broader technology ecosystem across organisations.

Dr Kalam was there for me as both my flag and my flagpole. People listened to what I said and helped in the best way they could. Working with Dr. Kalam, I met some of the best minds in scientific laboratories, universities and industries, and developed a great interdisciplinary network across organisations, breathing innovation into societal missions. One such contact was Dr S. Sridhar, whom I met at the CSIR-Indian Institute of Chemical Technology (IICT) during the development of a machine for creating water from atmospheric air in 2018 by Maithri Aquatech, a company founded by my friend M. Ramakrishna.

Hailing from a Tamil lineage in southern India, Sridhar’s father served in the Indian Army and settled in Hyderabad, where Sridhar was born and brought up. He graduated in Chemical Engineering and went on to specialise in molecular separation. Any young scientist faces a fork in life – one road leads to application, while the other leads to specialisation. On one path, you spread out over several areas; in another, you dig deep into one field. Dr Sridhar is unique in that, while he has delved deep into his chosen subject, he has kept the application of his work active by training 500 engineering and science graduates.

Dr Sridhar joined IICT as a Research Assistant in 1995, was promoted to Scientist in 1998, and has been working there ever since. His career exemplifies the progress of membrane technology in molecular separation. Over the years, Sridharhas developed pilot plants based on technologies that were patented as they evolved electrodialysis, nanofiltration, gas permeation, pervaporation, forward osmosis, membrane distillation and reverse osmosis, with capacities ranging from 500 to 5000 litres per hour for solvent recovery, effluent treatment and gas purification, serving the pharmaceutical, steel, textile, aroma and petrochemical industries. He has developed several indigenous membranes for fuel cellapplications.

Dr Sridhar has to his credit more than 70 water purification plants, ensuring safe drinking water for people living in remote areas, affected by waterborne diseases such as fluorosis, gastroenteritis, jaundice and typhoid, across ten states in India. Every purification method is unique and must be tailored to efficiently and reliably filter out the root cause, while also being affordable. Local people must be able to maintain these plants themselves. This is the challenge where most others failed, but Dr Sridhar proved otherwise. Other significant societal contributions with far-reaching impacts include an import-substitute device for producing ultrapure medical-grade water and an affordable, washable, multi-layered facemask to counter COVID-19, which led to the creation of several start-ups.  

 Molecular separation technology stands as a cornerstone in the domains of chemistry, biochemistry and materials science. It involves isolating specific molecules from complex mixtures based on their physical and chemical properties, which is critical for applications spanning pharmaceuticals, environmental science, petrochemicals and biotechnology. In India, Prof Sirshendu De at IIT Kharagpur was the pioneer in this field.

The roots of molecular separation can be traced back to Russia with the development of chromatography. The introduction of solid-phase columns and more efficient detection methods allowed for enhanced resolution and sensitivity in analysing complex mixtures. Innovations in polymer science led to membranes with remarkable selectivity, durability and scalability, enabling their application in water purification and medical devices. Computational models and advanced materials transformed distillation setups, making them more energy-efficient and precise.

 The maturation of molecular separation technology has ushered in cutting-edge methodologies that leverage computational power and nanotechnology. Today, researchers rely on hybrid approaches that combine multiple separation techniques to achieve unprecedented levels of efficiency.

Nanotechnology plays a pivotal role in refining molecular separation. Nanoporous membranes, for instance, exhibit exceptional selectivity, enabling the separation of molecules based on their size, shape and chemical affinity. These membranes are increasingly utilised in desalination, gas separation and selective molecular capture applications.

With the discovery of natural gas, the Indian petroleum industry faced new challenges. Natural gas is a mixture of different molecules that must be purified from CO2 and H2S to enrich methane. The petrochemical industry heavily relies on C2 and C3olefins as feedstock to produce a vast array of chemical intermediates and final products. Separation of propylene from propane is essential for a wide range of chemical products, including plastics and solvents. Separation of CO2 from power plant off-gases or its direct air capture for agricultural purposes could reduce the increasingly alarming effects of global warming. Dr. Sridhar’s mission was to improve membrane permeability and selectivity, leading to higher yields and reduced energy consumption, which ultimately earned him the title of Molecular Separation Man of India, as evidenced by the 75 prestigious awards he has received. His work, his team, and above all, his zeal will not only benefit the Indian petroleum industry but also enhance its global role in the years to come.

The future of molecular separation technology is closely tied to interdisciplinary collaboration and technological convergence. Emerging fields such as quantum computing and synthetic biology are likely to redefine the boundaries of molecular separation. Quantum algorithms can simulate molecular interactions with unparalleled precision, paving the way for designing separation systems tailored to specific chemical profiles. Custom-designed biological molecules, such as engineered enzymes, can act as highly selective agents in molecular separation processes, opening new horizons in medicine and materials science.

The maturation of molecular separation technology reflects humanity’s unwavering quest to manipulate matter at its most fundamental level. From early chromatography to cutting-edge nanotechnologies, this field continues to evolve, addressing global challenges and enabling scientific breakthroughs. As researchers and industries forge ahead, the transformative potential of molecular separation will undoubtedly shape the future of science, technology and sustainability.

 It was natural for me to understand the role of Dr. Sridhar’swork in biomedical engineering. I recall meeting a Russian cardiologist in 1999 who used plasmapheresis to separate cholesterol from blood, a process similar to dialysis. A few sessions of plasmapheresis per year can help alleviate the side effects of statins. Russians also remove blood ammonia by this process to help the liver recover. These are all proven methods and established technologies, but their wider application is fraught with commercial forces and the formidable medical-pharmaceutical industry.

As a scientist, Dr Sridhar feels that molecular separation technologies are integral to drug development and diagnostics. Affinity chromatography, for example, is used in the purification of monoclonal antibodies and other biologics. Moreover, microfluidics-based separation systems are gaining traction for their capacity to isolate single cells or molecules in diagnostics and genomics research.

May the tribe of people like Dr. Sridhar increase, and may the culture of working across boundariesspanning science, engineering, computer science, medicine, pharmaceuticals and more remain open to the exchange of new ideas. Molecular separation technology stands at the frontier of scientific innovation, offering unparalleled opportunities to revolutionise industries ranging from healthcare and agriculture to energy and manufacturing. This cutting-edge methodology enables the precise isolation, purification, and manipulation of molecules, driving economic growth while addressing critical environmental and societal challenges.  

Molecular separation technology represents a transformative force in the global economy, offering solutions that enhance efficiency, sustainability, and profitability across industries.The fear that AI will take away jobs is real. However, new jobs will also be created, and people will be employed in making things more efficient and affordable. That it is happening in India augurs well.

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10. Lila: Book Review

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10. Lila: Book Review

I read Robert Pirsig’s Zen and the Art of Motorcycle Maintenance in the 1990s, and when Lila: An Inquiry into Morals was published in 1991, I bought that too. However, I failed to capture its content at that time. It remained on my bookshelf unread. The news of his death in April 2017 made me pick up this book from the shelf and read it. And once I started reading it, I could not put it down.

This book draws many parallels with Zen and the Art of Motorcycle Maintenance. Here, instead of a motorcycle, Pirsig sails on his yacht. Instead of going westwards from Minnesota to California, he sails along the Hudson in New York State from Troy to Sandy Hook, east of New Jersey. Instead of his son being a pillion rider, he picks up an unknown woman from a nearby boat, purely as a situation. This woman is Lila, single and struggling with insanity. But here the similarity ends. While Zen explored the idea of values, morals are examined here.

In the book, Pirsig attempts to build the concept of Dynamic Quality as an irresistible and indomitable cosmic force that drives humanity to create, improve, and evolve. This force naturally confronts the status quo – personal, social, economic and political – and motivates people to react. Some take up the challenge, but the majority decline. The majority lead comfortable lives within their families and workplaces. The few people triggered by this cosmic impulse for change emerge out of their comfort zones. They struggle. Some succeed, but most fail and live in despair.  Some even end up in insanity. In India, we refer to this invisible force as Brahman, and Practices like Yoga and Meditation help one remain stable in the turbulent winds of adversity. Indian society has its ways of coping with broken hearts through religion and other spiritual practices.

Pirsig expands the idea of the immortal Self dwelling within the mortal body (Atman) into his concept of multiple selves – biological, social and intellectual. When the balance and harmony between these is broken, an individual suffers from various physical ailments as well as mental disorders such as psychosis and neurosis, at times even ending up insane.

“The world comes to us in an endless stream of puzzle pieces that we would like to think all fit together somehow, but that in fact never do.” (Chapter 8, p. 102)

This book builds upon the concepts of Gestalt Therapy, as developed by Fritz Perls, and Self and Others, by R.D. Laing. I developed goosebumps imagining how these different books could have reached me. I found these books at various points in time, and though some, like Lila, had been with me for many years, I read them only when I was ready to absorb them.

I can now appreciate the necessity of incorporating a few minutes of meditation, or Dhyana, into one’s daily routine. Not only does it keep insanity away, but it also takes you forward on the path of evolution. Just as a forest is made up of many adjacent trees, so is human society. Just as trees are interconnected through birds and microorganisms, so also, people are interconnected through everyday transactions – with maids, drivers, vendors, co-workers, one’s supervisors, students, subordinates, and so on. A Lila is living inside all of us – frightened, bewildered and confused. Learn to take care of her fears and anxieties, and calming them down is the only way to remain sane in this insane world.

9. The Glass Palace: Book Review

9. The Glass Palace: Book Review

9. The Glass Palace: Book Review

I suffered a cardiac arrest on January 6, 2004, but luckily, as I was in a hospital setting and with Cardiologist Dr. B Soma Raju, I was resuscitated in time. A month later, on February 6, I was operated upon by heart surgeon Dr. M. Gopi Chand. On the eve of the surgery, Mr. Madhu Reddy, the Managing Director of the Universities Press publishing company, which had published Wings of Fire, visited me and gifted me the book The Glass Palace by Amitav Ghosh. I completed reading it while recovering after the surgery, even before I was discharged from the hospital. 

The Glass Palace follows the intertwined stories of Rajkumar, an Indian orphan, and the Burmese royal family, spanning several generations and locations, during the British invasion of Burma. The novel explores the themes of exile, displacement and the impact of colonialism on various societies, highlighting the struggles faced by individuals caught in the crossfire of political and social chaos. The book’s message is that the legacy of colonialism continues to shape societies and individuals, leaving lasting scars of displacement and social change.

Ghosh expertly weaves the personal tales of the people with meticulously documented historical events. The vivid landscapes and many cultural tapestries of Burma, India, and Malaysia come to life in his writing, which catches the spirit of each time and place. A profound sense of the interdependence of human lives across geography and time remains with readers as the novel comes to a close. The Glass Palace is proof that stories may transport audiences to another time and place while simultaneously shedding light on our history.

This novel left a big impression on me. After recovering, I met the Ambassador of Myanmar in New Delhi. I then visited Myanmar with Cardiologist Prof. P Krishnam Raju on a mission to develop an exchange programme introducing interventional cardiology there. During my stay there, I visited the Palace in Mandalay. Standing in the courtyard of Kuthodaw Pagoda on a nearby hill, I saw from a distance the jail where Lokmanya Bal Gangadhar Tilak was confined for six years, during which he used his time in exile to write the Gita Rahasya. I would later write a modern interpretation of this book.

After this trip, I also accompanied President Kalam on a State visit to Myanmar. In the following years, more than 100 doctors and nurses were trained at the Care Hospital, Hyderabad, as part of the exchange programme we have developed, which became a notable accomplishment. When I reflect on such things, I wonder whether things are already predetermined and whether what we think we are doing is happening through us. What if Mr. Madhu Reddy had given me some other book? What if I had not read the book? What if Prof. Krishnam Raju had not been able to spare time to travel to Myanmar?

This book remains very special to me, and I often read its passages to unwind.

“But if it were true that his life had somehow been moulded by acts of power of which he was unaware, then it would follow that he had never acted of his own volition; never had a moment of true self-consciousness. Everything he had ever assumed about himself was a lie, an illusion. And if this were so, how would he find himself now?” (Chapter 36, p. 461)

I consider Mr. Amitav Ghosh the best historical fiction writer of our time. He is our own V. S. Naipaul and Joseph Conrad in this genre of literature.

8. Les Misérables: Book Review

8. Les Misérables: Book Review

8. Les Misérables: Book Review

France was the first foreign country I visited in 1985. It was also the first time I boarded an aircraft. Everything looked like a dream during the daytime. Later, when I visited the United States and other European countries, I realised how the French people are different from other Westerners. Small talk doesn’t work in France. They won’t pick up the phone to talk to a stranger without a thoughtful approach. They are reluctant to answer questions like, “How are you doing?” and even get offended.

So, when I picked up this voluminous novel (exceeding 650,000 words) during the COVID-19 pandemic, I approached it with a sense of respect. However, after reading it, I can say without a doubt that if there is one timeless masterpiece of a novel I have read, it is Victor Hugo’s Les Misérables. This sweeping tale, set in post-revolutionary France, centres around the life of Jean Valjean. Valjean, a former convict, seeks redemption. He ended up in jail for trying to grab a loaf of bread to pacify his starving nephew and spent nineteen years rotting there.  Despite his attempts to lead an honest life, he is relentlessly pursued by Inspector Javert, whose rigid sense of justice leaves no room for compassion.

Valjean’s journey intersects with many strangers, revealing different facets of human nature and the products of an imperfect society. Fantine, a destitute mother forced into prostitution, leaves her daughter, Cosette, in Valjean’s care. Cosette’s love story with the passionate revolutionary Marius adds a romantic dimension to the narrative. The novel reaches its climax during the June Rebellion of 1832, where the characters’ fates become inextricably entwined amidst the chaos of the Parisian streets. Packed with action, suspense and gripping passages, it’s a book you can’t put down.

‘Les Misérables’ is a profound exploration of justice, mercy and the human spirit. Hugo delves into the injustices of the legal and social systems, portraying the struggles of the underprivileged and the marginalised—the novel advocates for compassion and forgiveness, suggesting that true justice must be tempered with mercy. “Teach the ignorant as much as you can; society is culpable in not providing a free education for all and must answer for the night it produces. If the soul is left in darkness, sins will be committed. The guilty one is not he who sins, but the one who causes the darkness.”

Through Valjean’s transformation, Hugo illustrates the possibility of redemption and the power of love and kindness to overcome past wrongs. The novel also highlights the impact of systemic poverty and the necessity of social change, urging readers to empathise with the plight of the oppressed.

“Love has no middle term; either it destroys, or it saves. All human destiny is this dilemma. No fate proposes more inexorably than love in this dilemma, destruction or salvation. Love is life, if not death—cradle, coffin, too. The same sentiment says yes and no in the human heart. Of all the things God has made, the human heart is the one that sheds most light, and alas! most nights.” (Vol. IV, book 8, p 863)

While reading the novel, I couldn’t stop crying for quite some time when Valjean dies in the end. “If the soul is left in darkness, sins will be committed. The guilty one is not he who sins, but the one who causes the darkness.” Ultimately, Les Misérables is a testament to the resilience of the human spirit and the enduring quest for freedom and equality. Hugo’s masterful storytelling and rich character development create a timeless epic that resonates with readers worldwide.

7. The Divine Comedy: Book Review

7. The Divine Comedy: Book Review

7. The Divine Comedy: Book Review

I visited Italy as part of a family trip through Western Europe, which included cities in Germany, Belgium, France, Switzerland, and Austria. In Italy, we visited Milan, Rome and Venice. Italy stands out for its architecture, but also its people with a distinct attitude. The most intriguing city was Venice, a grand city built on the water, with no roads—only boats navigating waterways.

Later, I learned that Italy was not always a unified country. The survivors of the Trojan War arrived at Florence, and there were constant fights between them and the locals. Even the Roman Empire did not last for 500 years. As for Venice, a city built on 118 islands, it was founded in the 5th century AD by refugees fleeing the Roman Empire and Germanic invasions. Over time, it developed into a significant maritime and trading power, becoming a key player in European and Mediterranean commerce. Of the countries I visited, Italy remained with me as a land of brilliance and arrogance.

The Divine Comedy, written by Dante Alighieri, a 13th-century Florentine, is an epic poem comprising 14,233 lines. It is divided into three equal parts: Inferno (Hell), Purgatorio (Purgatory), and Paradiso (Paradise). The poem narrates Dante’s journey through the three realms of the dead, lasting from the night before Good Friday to the Wednesday after Easter in the spring of 1300. It begins saying:

Midway along the journey of our life
I woke to find myself in a dark wood,
For I had strayed from the straight path. (Inferno, Canto I, lines 1-3)

The Roman poet Virgil guides him through Hell and Purgatory; Beatrice, Dante’s ideal woman, guides him through Heaven.

When you read Dante, you feel like you are watching a film. He creates scenes using metaphors and explains complex insights through dialogues between the characters. It is a wholesome teaching on Christian theology, with Hell, Purgatory and Heaven as allegorical representations of sin, penance and divine grace, respectively.

There are multiple circular steps, like stepped rings, for rising through repentance or falling into sin. The punishments in each circle are not arbitrary; they are designed to reflect the nature of the sin. For example, those who indulged in lust are tormented by a storm, as their passions were uncontrolled. Similarly, those who committed violence against others are punished with violence. Dante also depicts Pope Boniface VIII and Pope Nicholas III in Hell.

I am in love with this book for its craftsmanship. How can anyone create an entire imaginary realm and then put it into words so that the reader also reaches there? The scene I loved most is when Dante finds a crowd outside the first circle of Hell. These people are not allowed inside as they were neither good nor bad, but lacked the faith to be saved. Called Limbo, this is not a place of punishment; it’s also not a place of eternal joy. It’s a state of perpetual longing for what they cannot have. He meets Socrates, Aristotle and Julius Caesar here.

My favourite lines are:

“The only answer that I give to you is doing it,” he said.
“A just request is to be met in silence, by the act.” (Inferno, canto XXIV, lines 77-78)

Taking practical actions makes your life relevant. Mere words are not enough when responding to a just request. When a request is undeniably fair, the most effective way to respond is to take the necessary steps to meet the request. Not doing this will take you to hell, make no mistake about it.