Darning, known as Rafookari in Hindi, is an umbrella term for a mending technique used to repair holes or worn areas in fabric or knitted materials by weaving a new piece of cloth or thread into the existing material. Often done by hand, this practice was prevalent in...
Warriors of Light
Warriors of Light
In the Katha Upanishad, a parable of the “chariot” elucidates the intricate relationship between the body, the senses, the mind and the self (Atman). The chariot, a metaphor for the body, is akin to a vehicle that ferries the true self through life. The charioteer, symbolising the intellect (Buddhi), is not just a passive guide but an active force that steers individuals in making decisions and controlling their path. It embodies wisdom and discernment, leading the mind and senses. The horses, representing the senses, are the gateways through which we perceive the world — sight, hearing, taste, touch, and smell. They can be unruly, but with the charioteer’s (intellect’s) guidance, they can be harnessed to navigate life effectively. Life is portrayed as a journey, and the choices made along this journey can lead one either closer to or further away from the Ultimate truth and liberation.
आत्मानं रथिनं विद्धि शरीरं रथमेव तु।
बुद्धिं तु सारथिं विद्धि मनः प्रग्रहमेव च ॥ (1.3.3)
The passenger symbolises the self (Atman) — the essence of an individual who experiences life through the body. The passenger has to rely on the charioteer (intellect) to steer the chariot (body) in the right direction. The destination represents the ultimate Truth or liberation (Moksha). The goal of life is to reach this destination, which is the realisation of one’s true self and unity with Brahman (the ultimate Reality). The parable fundamentally teaches self-realisation, the role of the intellect, the control of the senses, and life’s journey. It underscores the significance of comprehending one’s true self (Atman) beyond the physical body and senses. Realising that one is the passenger within the chariot can spark a spiritual awakening. The charioteer’s skilful control over the horses (senses) to ensure the chariot moves smoothly highlights the necessity of wisdom and discernment in guiding our actions and decisions. Just as wild horses can lead the chariot astray if not controlled, uncontrolled senses can lead individuals away from the path of righteousness and self-realisation.
I met Bhooshan Sawant, born and brought up in Sawantwadi near Goa, after 11 years when he visited me, taking time off from his fortnight-long visit to his mother. I met Bhooshan in the late 2000s. He was travelling to network Indian scientific institutions with startups in the U.S., many of which had sprung from the biotechnology genius of Satish Chandran, a Keralite Indian-American who had been the Chief Technology Officer at Pfizer BioTherapeutics. I was struck by the freshness of their ideas, such as putting the poly (ethylene glycol) PEG strands on molecules, mainly peptides, proteins, and antibody fragments, which can make many treatments less hazardous and more successful. “ A child carrying a gas-filled balloon in a crowded fair so as not to be missed,” Bhooshan described it. Bhooshan was then in his 30s, a handsome, tall, lean man who radiated compassion and resilience.
Through Bhooshan, I met Dr Seetharama Acharya, then Professor of Oncology and Medicine at Albert Einstein College of Medicine, New York; Dr Girish Sahni, who was at the time Director of CSIR – Institute of Microbial Technology (IMTech), Chandigarh; Dr Subramanian Iyer, Affiliate Professor of Biological Sciences at Florida Atlantic University; and Dr Satish Chandran. I stayed at Bhooshan’s home in Princeton, New Jersey, for a week, and he drove me to the Perelman School of Medicine at the University of Pennsylvania. I will never forget seeing The Liberty Bell, an iconic symbol of American independence located in Philadelphia. We managed to organise active work on breeding IgY protein in eggs but needed help. Later, when the COVID-19 pandemic struck, we truly regretted missing a great opportunity and learnt that no single day must be wasted due to the whims and fancies of those born as if to stall new ideas and oppose progress.
In the decade since I met him, Bhooshan’s son Shloka has grown up, and his wife Aarti has progressed in her job at the Bank of New York. Bhooshan ended his work in the IgY area but retained his investment in that company when he found a new calling. We first respectfully remembered two great scientists who left us. Dr Acharya, aged 82, died on March 16, 2024, at the Virginia Mason Medical Center ICU due to complications from head and neck cancer surgery. Dr Girish Sahni passed away suddenly on August 19, 2024. He was 68. We felt that the genius of Dr Satish Chandran had not been fully harnessed into valuable products and that we must find a way to see that he passed on his ideas to younger scientists before it was too late.
Bhooshan took me on an emotional roller coaster when he mentioned that he saw his father, Dr Suresh Sawant, serving the poor in the surrounding villages of Sawantwadi with little financial gain. He would end up providing medicines to many people who had nothing to give, and his mother would even prepare food for many who had walked for hours to reach there. Bhooshan left for the U.S. to work in the pharmaceutical industry in the late 1990s. He struggled for years to enter the highly regulated and fiercely protected sector, barely earning his daily bread, but never lost track of making his name in science. He has learnt the hard way by practising and learning from elders. He internalised the phrase, ‘उत्तिष्ठत जाग्रत प्राप्यवरान्निबोधत’ in the Katha Upanishad (1.3.14) meaning, ‘Get up, wake up and listen to those who walked before you’, in his living.
Moved by the plight of the parents of children born with autism, Bhooshan decided to make this tender but challenging area his chosen field. It happened through his chance meeting with Dr Edward Quadros, a native of Mangaluru, in SUNY Downstate, NY. By this time, Bhooshan had developed the sensitivity to recognise the subtle moves of the ‘hand of Providence’, which never pushes but provides gentle nudges at the right moments, like a shepherd to the cows or sheep in his care. He contemplated that the chemistry in diagnostics was nearing its peak and that new advancements would come from physics as nanotechnology matured. Dr Satish Chandran also opined that all material and life is ‘one’ at the ‘nanoscale’ of existence.
There are always two ways of looking at suffering. One is the way of compassion; your heart goes out to share the pain of others. The second way is of innovation, where your brain is activated to find a solution for relieving that pain. Let my brain remove your pain, Bhooshan felt and decided to align his energies with the emerging field of personalised medicine, which improves patient outcomes and quality of life. He created a life sciences company, ReligenDX, to develop and implement new and innovative diagnostic testing.
Luck favours the prepared. Soon, his company developed a diagnostic blood test that screens for autoantibodies to the Folate Receptor Alpha (FRa). The presence of Folate Receptor Autoantibodies suggests that folate (vitamin B9), which is an essential vitamin for proper growth and neurological function, is not being correctly transported to the brain and into the cerebrospinal fluid (CSF), among other tissues where FRa may be found.
Many of his well-wishers cautioned that getting a new test approved for clinical practice in the U.S. system, which is followed almost universally for its credibility, was a Herculean task. However, Bhooshan felt there was no harm in being a Hercules and failing rather than pretending to live a happy life doing mundane things, going on picnics, and wandering in shopping malls, buying cosmetics, designer clothes, fancy shoes, and “electronic toys.”
Hercules was given 12 labours to complete to appease Hera, his stepmother and the wife of king of gods Zeus. Each task was considered impossible, including defeating the Hydra and retrieving Cerberus from the Underworld without dying. Bhooshan made the early detection of Fra, which he saw as the Hydra, his mission, as these autoantibodies have been found in autism, schizophrenia and depression. All patients need rescue from the ‘underworld’ of their sickness. “Darkness has no existence of its own; it is merely the absence of light,” he mused. I am blessed to have met some great warriors of light, Bhooshan being the youngest and perhaps the bravest of them all.
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